Among many of the improvements you can enjoy in MySQL 5.6, there is one that addresses a huge operational problem that most DBAs and System Administrators encounter in their life: schema changes.
While it is usually not a problem for small tables or those in early stages of product life cycle, schema changes become a huge pain once your tables get a significant amount of data. Planning for maintenance is becoming more and more difficult, and your worldwide users want the service to be up and running 24/7, while on the other hand, your developers desire to introduce schema changes every week.
Read my full article on MySQL Performance Blog