I came across as interesting situation with MySQL that I had not come across before. Most people would not have come across this problem either as the majority of MySQL installs are either single server based. If there are multiple servers, then they are usually the same platform or very close eg. Linux on x86 etc.
The issue I came across was actually in respect to a MySQL Forums entry and this guy who was trying to replicate from Unix to Mac OS X. The problem was explained that the replication showed the status as normal, the read_master_pos_log and the exec_master_pos_log were all fine, and the relay logs were working. There was no errors showing and the replication seemed to be going through according to all system status reports. The issue was that no data was going in to the tables.