We were using memcache in our application for a long time and it helped a lot to reduce DB servers load on some huge queries. But there was a problem (sometimes called a “dog-pile effect”) - when some cached value was expired and we had a huge traffic, sometimes too many threads in our application were trying to calculate new value to cache it.
For example, if you have some simple but really bad query like
SELECT COUNT(*) FROM some_table WHERE some_flag = Xwhich could be really slow on a huge tables, and your cache expires, then ALL your clients calling a page with this counter will end up waiting for this counter to be updated. Sometimes there could be tens or even hundreds of such a queries running on your DB killing your server and breaking an entire application (number of application instances is constant, but more and more instances are locked waiting for a counter).