Martin Brown’s blog shows a pretty good way of navigating the MySQL Reference Manual. It’s worth noting, however, that finding the different topics has been a lot easier since mysql.com started using a Google appliance for its search.
I use the documentation all the time and have been doing so for years (I won’t claim that I can remember +2000 pages worth of ever-changing content). A few years back, I stopped using the search box on dev.mysql.com because the result sets were enormous, with lots of unrelated references. My technique was to do a Google site search:
For replication use the expression: replication